The Klingon Empire is ruled by a Chancellor with the support of the Klingon High Council. When the Chancellor dies, his replacement is chosen by an Arbiter of Succession, who chooses from eligible candidates (usually Council members themselves) based on rules established in Klingon law. A Chancellor with some foresight can decide who will be the Arbiter of Succession after his own death.
A clone of the Empire's founder, Kahless, was recently crowned Emperor, but his title is ceremonial and carries no real governmental authority.
Klingon physiology makes them considerably tougher than humans; many of their major organs have redundancies that allow them to survive injuries that would kill a human. Klingons tend to be physically stronger than humans, but this is probably more a result of widespread martial training than a genetic trait.
The Klingon Empire controls a large volume of space that shares borders with the Romulan Star Empire and the United Federation of Planets. The full extent of their territory is unknown, but it is probably not substantially greater than that of either of its neighbors.
The Klingons are one of the most formidable military powers in the Alpha Quadrant. Martial traditions are so widely revered in Klingon society that almost every Klingon has at least basic military training. Similarly, virtually every Klingon has personal weapons and body armor, and attaining any sort of political influence requires a good military service record. Klingon technology is comparable to that of the other major Alpha Quadrant powers, and they invest heavily in military assets.
In an alternate timeline, the Klingon Empire was shown to be decisively winning a war against the United Federation of Planets (TNG, "Yesterday's Enterprise").