- Captain: Erika Benteen
- Class: Excelsior-class (Refit)
- Registry: NCC-42768
The USS Lakota (NCC-42768) was an Excelsior-class starship in the 24th century. In 2372, it was refitted with additional phaser banks, quantum torpedoes, and stronger shields. It was put under the command of Captain Erika Benteen in 2372. It later engaged the USS Defiant. Admiral Leyton ordered the Lakota to destroy the Defiant; however, Captain Benteen decided he had gone to far and communicated with the Defiant, instead.