The Officio Assassinorum is an organization of the government of the Imperium of Man that trains and equips a number of specialized assassins to remove individual enemies of the state. The Officio Assassinorum is divided into various temples which specialize in different strategies.
- Vindicare: Trains assassins in the use of stealth equipment and long-range sniper rifles.
- Eversor: Creates drug-fueled, close-combat killing machines to terrorize enemy command structures.
- Callidus: Trains assassins to infiltrate opposing organizations to reach critical targets, specializing in the use of polymorphine, a drug the assassins use to disguise themselves by physically altering their bodies.
- Culexus: Trains anti-psychic "pariahs" to locate and kill psychic opponents.
- Venemum: Trains assassins in the preparation and use of poisons.