Kes
Shortly after being in telepathic contact with Species 8472, the occasional psychic powers Kes displayed suddenly and inexplicably increased to a massive degree, forcing her to leave the ship. Afterwards, she "evolved" into a non-corporeal life form (although as usual, the process had little resemblance to real-world evolution), and finally did something useful for Voyager, propelling the ship 10,000 light-years closer to Earth, conveniently bypassing Borg space.
Some years later, she again underwent an inexplicable change, "de-evolving" back into an Ocampan with powerful psychic abilities and anger management issues. Despite coming up with a bizarre plan to get herself killed in the past by handing Voyager over to the Vidiians, Janeway talked her out of it, and Kes took a shuttle back to the Ocampa homeworld, never to be seen again.
Blind as a bat
She once stated she didn't think Janeway was stupid and that the genocidal bitch actually cared about her crew[1].